Meeting Program
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Organizers:
Graciana Diez Roux, Telethon Institute of Genetics and Medicine, IT
Chiara Di Malta, Telethon Institute of Genetics and Medicine, IT
Gennaro Napolitano, Telethon Institute of Genetics and Medicine, IT
Carmine Settembre, Telethon Institute of Genetics and Medicine, IT
Confirmed speakers:
Monther Abu-Remaileh, Stanford University, US
Alberto Auricchio, Telethon Institute of Genetics and Medicine, IT
Juan Bonifacino, National Institutes of Health, US
Thomas Braulke, University Medical Center Hamburg, DE
Francesco Cecconi, Università Cattolica del Sacro Cuore, IT
Antonella De Matteis, Telethon Institute of Genetics and Medicine, IT
PierPaolo Di Fiore, Istituto Europeo di Oncologia, IT
Chiara Di Malta, Telethon Institute of Genetics and Medicine, IT
Ivan Dikic, Goethe University Frankfurt, DE
Alejo Efeyan, Centro Nacional de Investigaciones Oncológicas, SP
Volker Haucke, Leibniz-Forschungsinstitut für Molekulare Pharmakologie Berlin, DE
Elizabeth Henske, Harvard Medical School, US
Lukas Huber, Medizinische Universität Innsbruck, AT
James Hurley, University of California, Berkeley, US
Judith Klumperman, University Medical Center Utrecht, NL
Gennaro Napolitano, Telethon Institute of Genetics and Medicine, IT
Mario Pende, Institut Necker Enfants Malades, FR
Rushika Perera, University of California, San Francisco, US
Frances Platt, University of Oxford, UK
Paul Saftig, Christian-Albrechts-Universität zu Kiel, DE
Carmine Settembre,Telethon Institute of Genetics and Medicine, IT
Meng Wang, Baylor College of Medicine, US
Marino Zerial, Human Technopole, IT
Huda Zoghbi, Baylor College of Medicine, US
Roberto Zoncu, University of California, Berkeley, US
Scientific Program
September 19th, 2024
14:00 - 14:30 Registration
14:30 - 15:00 Meeting Opening - Welcome
Lysosome biogenesis and function - Chair: Chiara Di Malta and Ivan Dikic
15:00 – 15:30 Juan Bonifacino
Mechanisms of axon dysfunction in lysosome-transport disorders
15:30 – 16:00 Judith Klumperman
The HOPS complex: integrating lysosomal trafficking pathways
16:00 – 16:30 Paul Saftig
What did we learn from research on lysosomal membrane proteins?
16:30 – 16:45 Coffee break
16:45 – 17:15 Antonella De Matteis
A PIPeline for drug discovery in Lowe Syndrome
17:15 – 17:45 Thomas Braulke
Golgi-regulated homeostasis of lysosomes
17:45 – 18:00 Friederike Zunke
Structure-function analyses of ß-glucocerebrosidase (GCase) and LIMP-2: implications for novel treatment strategies in Gaucher's and Parkinson's disease (short talk selected from submitted abstracts)
September 20th, 2024
Lysosomal signalling - Chair: Judith Klumperman and Paul Saftig
09:00 – 09:30 Roberto Zoncu
Decoding lysosomal nutrient signaling in cellular growth and repair
09:30 – 10:00 Meng Wang
Lysosomal signals in aging and longevity
10:00 – 10:30 James Hurley
Structural insights into canonical and non-canonical mTORC1 signaling at lysosomes
10:30 – 10:50 Coffee break
10:50 – 11:20 Volker Haucke
Lipid switches in cell physiology: from nutrient signals to disease
11:20 – 11:50 Lukas Huber
LAMTOR: coordinating protein complex dynamics for lysosomal signaling
11:50 – 12:20 Gennaro Napolitano
Selective modulation of mTORC1 signaling
12:20 – 12:35 Zhicheng Cui
Structural basis for mTORC1 phosphorylation of non-canonical and canonical substrates (short talk selected from submitted abstracts)
12:35 – 12:50 Dominic Winter
Alterations in lipid homeostasis affect ragulator-mediated lysosomal positioning (short talk selected from submitted abstracts)
12:50 – 14:50 Lunch and Poster Session
14:50 – 15:30 Keynote Speaker: Huda Zoghbi
Pathogenesis studies of neurodegenerative diseases: the rare informs the common
Lysosome and cancer - Chair: Rushika Perera and Roberto Zoncu
15:30 – 16:00 Alejo Efeyan
Cell-autonomous vs. paracrine effects of the RagC-mTORC1 axis in cancer and aging
16:00 – 16:30 Chiara Di Malta
Lysosomal deregulation in MiT/TFE-associated cancer
16:30 – 16:50 Coffee break
16:50 – 17:20 Mario Pende
Canonical mTOR signaling in Tuberous Sclerosis and senescence
17:20 – 17:50 Elizabeth Henske
Lysosomes in Tuberous Sclerosis Complex: innocent bystanders or tumor drivers?
17:50 – 18:20 Marino Zerial
Role of forces in membrane dynamics and tissue morphogenesis
18:20 – 18:35 Alessia Calcagnì
A 'multifocal' Birt-Hogg-Dubé (BHD) mouse model to study kidney cystogenesis and tumorigenesis pathways (short talk selected from submitted abstracts)
19:00 - 20:00 Toast and Light Dinner
September 21st, 2024
Autophagy and Endocytosis - Chair: Elizabeth Henske and Gennaro Napolitano
09:00 – 9:30 PierPaolo Di Fiore
Endocytosis and cancer
9:30 – 10:00 Rushika Perera
Lysosomal lipid regulation in pancreatic cancer
10:00 – 10:30 Francesco Cecconi
Novel forms of selective autophagy and disease: when organelle catabolism meets biomedicine
10:30 – 10:50 Coffee break
10:50 – 11:20 Carmine Settembre
Substrate selectivity during bulk autophagy
11:20 – 11:50 Ivan Dikic
Tumor immune evasion through IRGQ-directed autophagy
11:50 – 12:05 Alison Forrester
Desialylation controls glycolipid-lectin driven formation of clathrin-independent carriers (short talk selected from submitted abstracts)
12:05 – 12:20 Gabriele Zaffagnini
How endolysosomal super-organelles manage protein aggregation in mammalian oocytes (short talk selected from submitted abstracts)
12:20 – 14:00 Lunch and Poster Session
Session 2: Lysosomal Storage Diseases - Chair: Huda Zoghbi and Carmine Settembre
14:00 – 14:30 Monther Abu-Remaileh
A cell-type lysosomal protein Atlas in the brain identifies a novel neuronal lysosomal storage disease
14:30 – 15:00 Frances Platt
Understanding and treating Niemann-Pick disease type C
15:00 – 15:20 Coffee break
15:20 – 15:50 Alberto Auricchio
ExpEditing AAV gene therapy
15:50 – 16:05 Stefania Crippa
An innovative platform approach for the parallel development of HSPC-GT for rare/ultra-rare lysosomal storage disorders with severe skeletal manifestations (short talk selected from submitted abstracts)
16:05 – 16:20 Philipp Alberts
Discovery of a novel Niemann Pick type C (NPC) disease modifier and development towards its clinical application (short talk selected from submitted abstracts)
16:30 Closing remarks